In most cases, the first sign of infection with the bacterium that causes
Lyme disease is the Lyme disease rash. This is usually a circular rash called erythema migrans, or EM. This rash occurs in approximately 70-80 percent of people infected with Lyme disease, and begins at the site of a tick bite after a delay of 3-30 days. A distinctive feature of the Lyme disease rash is that it gradually expands over a period of several days, reaching up to 12 inches (30 cm) across. The center of the rash may clear as it enlarges, resulting in a bull's-eye appearance. It may be warm, but is not usually painful. Some patients develop additional Lyme disease rashes in other areas of the body after several days.
- Fatigue
- Chills
- Fever
- Headache
- Muscle and joint aches
- Swollen lymph nodes.
In some cases, these may be the only symptoms of infection.